FridayOL

Weight Loss Drug Reality Check: Singaporeans See Smaller Results Than Clinical Trials Show

Reuters

Weight loss drugs like semaglutide (Ozempic, Wegovy) and liraglutide (Saxenda) have garnered significant attention for their potential to help individuals shed substantial pounds. Clinical trials often showcase remarkable results – participants losing a significant percentage of their body weight over a defined period. These trials are carefully controlled environments, with participants under close medical supervision, adhering to strict dietary guidelines, and engaging in regular exercise. However, the real-world setting is far more complex.

The new study highlights a crucial difference between clinical trial outcomes and the experiences of patients in Singapore and elsewhere. Several factors contribute to this discrepancy:

• Dietary Adherence: Maintaining a strict diet alongside medication is key. In real life, sticking to rigid dietary restrictions can be challenging.
• Exercise Habits: Clinical trials often incorporate structured exercise programs. Many individuals don't consistently maintain this level of activity.
• Dosage & Individual Response: The optimal dosage and individual response to these medications can vary. Some individuals may not tolerate the full prescribed dose, or their bodies may respond differently.
• Plateau Effect: Weight loss often plateaus over time, even with medication and lifestyle changes. This is a natural physiological response.
• Comorbidities and Medications: Existing health conditions and other medications can influence the effectiveness of weight loss drugs.

While specific Singaporean data may not be fully available without the study itself, the general trend observed in similar studies suggests that patients in Singapore are experiencing more modest weight loss compared to the figures reported in clinical trials. This isn't necessarily a failure of the medication itself, but rather a reflection of the challenges in translating clinical trial protocols to everyday life.

It's crucial to approach weight loss drugs with realistic expectations. They are tools to *aid* weight management, not magic bullets. Here's what experts recommend:

• Consult a Healthcare Professional: Discuss your weight loss goals and suitability for medication with a doctor.
• Combine Medication with Lifestyle Changes: Weight loss drugs are most effective when combined with a healthy diet and regular exercise.
• Focus on Long-Term Habits: Prioritize sustainable lifestyle changes rather than quick fixes.
• Monitor Progress and Adjust: Regularly track your weight and discuss any concerns with your doctor. Dosage adjustments or alternative strategies may be necessary.
• Be Patient: Weight loss is a journey, and there will be ups and downs.

Ultimately, achieving and maintaining a healthy weight requires a holistic approach that addresses diet, exercise, sleep, stress management, and overall well-being. Weight loss drugs can be a valuable part of this equation for some individuals, but they should be used responsibly and under medical guidance.